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Genetic Archaeology
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GENETIC ARCHAEOLOGY // CATEGORY

Metabolism

Genes that control metabolic processes and lipid metabolism.

Metabolism & Weight: The DNA behind the scale

Why can some people eat whatever they want while others struggle with every gram? The answer is often found in the genes for appetite control, fat storage and energy conversion. Genetics explains about 40-70% of the differences in body weight.

weight

Genes like FTO (the "fat mass gene") influence our feelings of hunger and satiety. Certain variants lead to a lower feeling of satiety, so that those affected automatically consume more calories.

fat

The ADRB2 gene controls how effectively our body breaks down body fat during physical exertion. Knowledge about these variants helps to choose the right exercise strategy (Endurance vs. HIIT).

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Worth Knowing

Genetics is not fate. Knowing your predisposition allows you to get the best out of your biology through a targeted lifestyle.

Gene Profiles in this Category

APOE
Gene Profile

APOE

APOE encodes Apolipoprotein E, a protein playing a key role in lipid metabolism and associated with Alzheimer’s risk….

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FTO
Gene Profile

FTO

FTO is strongly associated with obesity risk. Variants influence appetite and energy metabolism….

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APOA1
Gene Profile

APOA1

APOA1 encodes the major protein of High-Density Lipoprotein (HDL), often referred to as ‘good cholesterol’….

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APOB
Gene Profile

APOB

APOB encodes the major protein of Low-Density Lipoprotein (LDL), the so-called ‘bad cholesterol’….

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NOS3
Gene Profile

NOS3

NOS3 produces nitric oxide (NO) in blood vessels, essential for vasodilation and blood pressure regulation….

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G6PD
Gene Profile

G6PD

Encodes a key enzyme in the pentose phosphate pathway. Deficiency leads to hemolytic anemia upon exposure to certain drugs or foods (Favism)….

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PAH
Gene Profile

PAH

Encodes the enzyme converting phenylalanine to tyrosine. Mutations lead to Phenylketonuria (PKU), a treatable metabolic disorder….

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LDLR
Gene Profile

LDLR

Encodes the LDL receptor which removes cholesterol from the blood. Mutations lead to Familial Hypercholesterolemia and high heart attack risk….

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CYP2D6
Gene Profile

CYP2D6

CYP2D6 is one of the most important enzymes for drug metabolism (e.g., antidepressants, beta-blockers, painkillers)….

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AMY1
Gene Profile

AMY1

AMY1 encodes salivary amylase, an enzyme starting starch digestion in the mouth. AMY1 copy number varies greatly between people….

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Frequently Asked Questions

Is obesity genetic?
There is a predisposition. Many genes influence how much fat we store and how strong our hunger is. But the environment (availability of food) decides whether these genes become active.
Can genes prevent weight loss?
Prevent? No. But they can make it harder. Knowing your metabolic type helps to set realistic goals and choose the right diet.
What does insulin sensitivity mean?
It describes how well cells respond to insulin. Genes like TCF7L2 influence the risk of insulin resistance, which can lead to diabetes and weight problems.
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