G
Genetic Archaeology
GENETIC ARCHAEOLOGY // PROFILE

SOD2

Superoxide Dismutase 2

CHR 6
6q25.3

Overview

SOD2 protects mitochondria (the energy powerhouses of our cells) from oxidative damage by neutralizing highly reactive superoxide radicals.

📍 Chromosomal Position

6q25.3 (Chromosome 6)

🧬 Gene Category

Detoxification / Antioxidants

🔬 Inheritance

Complex

📊 Prevalence (rs4880)

Val/Ala (Heterozygous): ~50%

Function & Significance

The SOD2 enzyme is the primary line of defense against reactive oxygen species (ROS) within the mitochondria. Since free radicals are constantly produced during energy production, efficient SOD2 function is essential for cellular health and longevity.

🍎 Support through Nutrition

Individuals with a genetically determined lower SOD2 activity (TT genotype at rs4880) may particularly benefit from a diet rich in antioxidants as well as manganese (an important cofactor for SOD2).

🧬 Relevant SNP: rs4880

The Val16Ala variant influences the transport of the enzyme into the mitochondria:

rs4880
6:160114082
Allele 1

C

/

Allele 2

T

Interpretation:
C (Ala): Higher efficiency in import into mitochondria (stronger protection).
T (Val): Lower import efficiency. Carriers of the TT genotype often have a higher oxidative load.

📚 Data Sources

  • OMIM: #147460 – Superoxide Dismutase 2; SOD2
  • dbSNP: rs4880
  • PubMed: Mitochondrial SOD2 and its role in human health.

Biological Function

The SOD2 enzyme is the first line of defense against reactive oxygen species (ROS) in mitochondria. Reduced activity increases oxidative stress within cells.

Associated Conditions

Cardiovascular Diseases Neurodegenerative Diseases Increased Inflammation Risk
Molecular Analysis

Analyzed Markers

rs4880 Modifier
Pos: 6:160114082 | Alleles: C/T

Val16Ala - C-allele (Ala): Higher efficiency in transport to mitochondria. TT (Val/Val): Increased need for antioxidants.