Overview
GSTP1 is an important enzyme in Phase II detoxification. It neutralizes carcinogenic substances, medications, and products of oxidative stress by binding them to glutathione, making them water-soluble and excretable.
11q13.2 (Chromosome 11)
Detoxification
Complex / Codominant
Val allele: ~35% in Europe
Function & Significance
The GSTP1 enzyme protects cells from damage caused by reactive compounds. It is particularly important for protecting tissues in the lungs, breasts, and prostate from environmental toxins such as polycyclic aromatic hydrocarbons (e.g., from smoke or exhaust fumes).
🌿 Natural Support
Cruciferous vegetables such as broccoli, Brussels sprouts, and kale contain substances (glucosinolates) that can stimulate the activity of GST enzymes and thus support detoxification performance.
🧬 Relevant SNP: rs1695
The Ile105Val variant changes the binding efficiency for certain toxins:
11:67585218
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Interpretation for ancestry/raw data:
A (Ile): “Standard” variant with normal enzyme stability.
G (Val): Leads to lower thermal stability of the enzyme and altered detoxification capacity. Homozygous carriers (G/G) may exhibit reduced protective performance against certain carcinogens.
📚 Data Sources
- OMIM: #134660 – Glutathione S-Transferase P1; GSTP1
- dbSNP: rs1695
- PubMed: GSTP1 polymorphisms and environmental toxin interaction.
Biological Function
Associated Conditions
Analyzed Markers
Ile105Val - G-allele (Val): Reduced enzyme activity and altered affinity for certain substrates.